Reproductive Immunology: Open Access

Neuroimmunomodulation Theory of Alzheimer's Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease, the most common cause of dementia in senile population, characterized by behavioral disorders, loss of memory and cognitive impairment. According to the World Health Organization, AD represents around 12% of people over 65 worldwide. On the basis of the two main protein aggregates, neurofibrillary tangles (NFT) and amyloid plaques (AP), several attempts to explain the genesis of the disease have been proposed. Current research indicates that pathological hyperphosphorylated forms of the microtubuleassociated protein tau, is the main precursor for AD onset, with a paramount molecular mechanism based on neuroinflammatory processes.

Author(s):

R B Maccioni

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