Reproductive Immunology: Open Access

Innate Immunity as a Pivotal Player in Mobilization of the Hematopoietic Stem Cells from Bone Marrow into Peripheral Blood

In steady state conditions low number of HSPCs always circulates in peripheral blood (PB) and lymph and undergoes a circadian rhythm in their PB circulation, with the peak occurring early in the morning and the nadir at night. The number of circulating HSPCs increases in PB in response to (1) systemic or local inflammation, (2) strenuous exercise, (3) hypoxia and (4) tissue/organ injuries. Moreover, in clinical settings, administration of some agents may induce forced egress of HSPCs into PB and increase their number in PB up to 100 fold in a process known as pharmacological mobilization. Such drugs include cytokine granulocyte colony stimulating factor (G-CSF) and the small molecular CXCR4 antagonist AMD3100; known as Plerixafor. Pharmacological mobilization is exploited as a means to obtain HSPCs for hematopoietic transplantations.

Author(s):

Mariusz Z Ratajczak

Abstract | PDF

Share this