Reproductive Immunology: Open Access

Dissecting the Role of Fractalkine Receptor during the Experimental Autoimmune Encephalomyelitis: New Approach Utilizing a Humanized Animal Model

Fractalkine is a transmembrane chemokine expressed by neurons and peripheral endothelial cells, which acts both as an adhesion molecule and as a soluble chemoattractant upon proteolytic cleavage. In the CNS, fractalkine functions by signaling through its unique receptor, CX3CR1 expressed by microglia. Fractalkine/CX3CR1 signaling regulates microglia neurotoxicity in models of neurodegeneration. During experimental autoimmune encephalomyelitis (EAE), CX3CR1 deficiency confers exacerbated disease characterized by severe inflammation and neuropathology. Among the CX3CR1 human polymorphisms, the CX3CR1I249/M280 variant is present in ~20% of the population and exhibits reduced adhesion for fractalkine conferring defective signaling. However, the role of CX3CR1, microglia function and its effect on neuronal damage during multiple sclerosis remains unsolved. The aim of this study is to assess the effect of weaker signaling through the human CX3CR1I249/M280 receptor on EAE disease, axonal damage and expression of ciliary neurotropic factor (CNTF).

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Author(s):

Sandra M Cardona

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