Comparative Evaluation of Therapeutic Potential of Apiumgraveolens and Aloe vera on the Reproductive System of Cadmium Treated Male Rats

N K Sushanth; R Vijayaraghavan; S Vijayalakshmi; Senthilkumar Sivanesan

Abstract

Comparative Evaluation of Therapeutic Potential of Apiumgraveolens and Aloe vera on the Reproductive System of Cadmium Treated Male Rats

Efficacy of Aloe veravsApiumgraveolens on cadmium treated ratsCadmium (Cd) is a well-known environmental toxicant that is naturally present in air, water and soil. It causes dangerous health problems by generating reactive oxygen species. The reproductive system is most vulnerable to oxidative damage and therefore most affected by Cd. Zinc (Zn) is an essential antioxidant and a chelating agent that is capable of protecting the testis from Cd induced toxicity. Apiumgraveolens commonly known as Celery and Aloe vera are herbal plants rich in antioxidants and they improve various sperm parameters. Male Wistar albino rats were randomly divided into 11 groups. Control received 0.5% Carboxymethyl cellulose in distilled water; the experimental groups such as Cd received 10mg/Kg body weight of CdCl₂; Cd+Zn received 10mg/Kg bodyweight of CdCl₂₊40mg/Kg body weight of ZnCl₂; Cd+AV200 received 10mg/Kg bodyweight of CdCl₂₊200 mg/Kg body weight of Aloe vera; Cd+AV400 received 10mg/Kg body weight of CdCl₂₊400 mg/Kg body weight of Aloe vera; Cd+AV200+Zn received 10mg/Kg bodyweight of CdCl₂₊200 mg/Kg body weight of Aloe vera+ 40mg/Kg body weight of ZnCl₂; Cd+AV400+Zn received 10mg/Kg bodyweight of CdCl₂₊400 mg/Kg body weight of Aloe vera+ 40mg/Kg body weight of ZnCl₂; Cd+AG200 received 10mg/Kg bodyweight of CdCl₂₊200 mg/Kg body weight of Apiumgraveolens; Cd+AG400 received 10mg/Kg body weight of CdCl₂₊400 mg/Kg body weight of Apiumgraveolens; Cd+AG200+Zn received 10mg/Kg bodyweight of CdCl₂₊200 mg/Kg body weight of Apium graveolens+40mg/Kg body weight of ZnCl₂; Cd+AG400+Zn received 10mg/Kg bodyweight of CdCl₂₊400 mg/Kg body weight of Apium graveolens+40mg/Kg body weight of ZnCl₂all in 0.5% CMC. The hydroalcoholic extracts of Aloe vera and Apiumgraveolens were used in this experiment.