A retrospective Comparison of Clinical Outcome Following Conventional In-Vitro Fertilization (c-IVF) vs Intracytoplasmic Sperm Injection (ICSI) for 100% Teratozoospermia Patients

Objectives: To investigate whether ICSI could improve the clinical outcomes of the 100% teratozoospermia patients.

Methods: This study contained 200 IVF-ET and 216 ICSI-ET cycles from January 2013 to January 2016. The first cycle patients aged <40 years, with cycle day 3 FSH <10 mIU/mL and 8-12 antral follicles were included. Main outcome measure(s): clinical, obstetric and neonatal outcome.

Results: The characteristics of the patients showed no significant differences in the female’s age, Gn administration, Gn does, basal serum follicle-stimulating hormone, basal E2 value, endometrial thickness, infertile time, the number of retrieved oocytes and the number of transferred embryos between two groups (p>0.05). The proportion of blastocyst transfers was significantly higher in c-IVF group than ICSI group (41.00 versus 28.70%; p=0.008). We observed that the implantation (53.80 versus 44.85%; p=0.016) and clinical pregnancy (67.00 versus 60.19%; p=0.149) rates were higher in c-IVF group than those in ICSI group. In addition, the abortion (7.46 versus 16.15%; p=0.028) and ectopic pregnancy (0.75 versus 5.38%; p=0.028) rates were significantly lower in c-IVF group compared with ICSI group. The two groups showed no significant differences in obstetrical and neonatal outcomes (p>0.05).

Conclusions: For isolated 100% teratozoospermia patients, ICSI should not be considered to improve the clinical outcomes if the semen meet c-IVF standard in the first cycle.


Mingzhao Li, Xia Xue, Juanzi Shi

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